Mass Effect - SecuROM Activation Issues?

The SecuROM DRM is finally taking it’s toll it seems, as users are reporting activation problems. riftguy from BioWare forums has reported the activation problems he encountered:

By this time it was after midnight so I registered my game on the forums and posted for help. (See topic=631894, forum=127) The feedback I got was that my card was either going bad or ancient, and Mass Effect was just pushing it over the edge. So I went out and bought a new 8800GT on June 2nd and the game worked beautifully! I was so happy that I got it and couldn’t put it down – by the night of the 3rd I’d finished my first run through. Then I put the game down hoping the DLC would come out to give me even more new stuff to explore.

That was ten days ago. Today I decided to do another run through while waiting in order to try playing a renegade on a higher difficulty level. That’s when I got it. “The game can not start. For security reasons, only a limited number of machines can ever be licensed by a single purchase. This limit has been reached. Please purchase another registration code, reinstall, and then try again.”